ABSTRACTABSTRAKObjectives: This study aimed to prove the effect of different administrationof red fruit (Pandanus conoideusLam) extract and leuprolide on the expression of NF-B and endometrial implant width in mouse models of endometriosis.Materials and Methods: This study used completely randomized design with pre-post separated sample. The sample size was 36 female mice (Mus muculus), which were divided into 3 groups randomly. They were given with cyclosporine A, estrogen and endometrialtissue to form endometriosis model. Results: The mean expression of NF-Bin in treatment group receiving leuprolide (4.13 +0.70) and red fruit (2.70 +1.08) were significantly lower than that in control group (6.94 +1.007). Whereas, in treatment group receiving red fruit (2.70 +1.08), it was significantly lower than in those receiving leuprolide (4.13 +0.70).Mean endometrial implant width in treatment group receiving leuprolide (13.62 +3.21) and red fruit (8.93 +2.74) were significantly lower than that in control group (28.89 +8.28). Whereas, in treatment group receiving leuprolide (13.62 +3.21), it wasnot significantly higher than in those receiving red fruit (8.93 +2.74).Conclusion: The expression of NF-B was significantly lower after the administration of red fruit than leuprolide. The width of endometrial implant was not significantly lower afterthe administration of red fruit than after the administration of leuprolide.