ABSTRACT
Periodontitis is a multifactorial inflammatory disease which is generally caused by plaque
accumulation. Many studies have shown that
Porphyromonas gingivalis (Pg) is the main
etiological agent that contributes to chronic periodontitis. Scaling and root planing (SRP)
is the gold standard for periodontitis treatment. The use of antibiotics as additional
agents accompanying the SRP procedure has limitations that can cause resistance to
subgingival periodontal pathogens.
Peperomia pellucida (L.) Kunth
i.e betel leaf is a
natural ingredient that contains anti-inflammatory, antibacterial and antioxidant
properties. This study aimed to analyze the inhibition of
Peperomia pellucida (L.) Kunth
extract against Pg bacteria. Methods: The type of study used was an experimental
laboratory with a Post-Test Control Group Design research design which was divided into
6 treatment groups using the disk diffusion method with concentrations of
Peperomia
pellucida (L.) Kunth extract 25, 50, 75 and 100%, sterile aquades as a negative control
and Chlorhexidine as a positive control. Data analyses of One Way Anova and Post Hoc
Tukey were used Results:
Peperomia pellucida (L.) Kunth extract concentrations of 25,
50, 75, and 100% had an effect on reducing the growth of
Porphyromonas gingivalis
(p≤0,05), the average inhibition response was 14.40 mm at 25% concentration, 16.58
mm at 50% concentration and 19.30 mm at 75%, 21.88 mm at 100%
concentration.Conclusion:
Peperomia pellucida (L.) Kunth extract has an antibacterial
effect against
Porphyromonas gingivalis which has the potential to be used as a
periodontitis herb.