ABSTRACT : Background:The global percentage of con-traceptive users in women of reproductive age range (15-49 years) or women who are married is 62.7%. Combined oral contraceptives repre-sent 8.8% of the prevalence (more than 100 million women). COCs are very effective in preventing pregnancy, but like most medica-tions, combined oral contraceptives can be associated with a variety of side effects and risks, including venous thromboembolism (VTE) and stroke. This study aims to determine the estimated effect of combined oral contra-ceptives on venous thromboembolism and stroke on family planning acceptors by meta-analysis.Subjects and Method:Meta-analyzes were performed by searching for articlesfrom the Google Scholar, PubMed, Research Gate, Sco-pus, Springer Link, and Science direct data-bases. The keywords used in the search for the article included “oral contraceptive” OR “com-bined oral contraceptives” OR “risk factor” AND “venous thrombolism” OR “VTE” AND “stroke” AND “family planning”. The inclusion criteria in this study were full text articles, from 2000-2020, with a case-control study design. The article analysis was carried out using RevMan 5.3. Results:There are 15 articles analyzed.The results showed that combined oral contra-ceptives increased the incidence of venous thromboembolism and stroke in family plan-ning acceptors (aOR 2.95; 95% CI = 1.80-4.84; p <0.001); (aOR 1.50; 95% CI = 1.30-1.74; p <0.001). The results of the meta-analysis showed a publication bias between the use of combined oral contraceptives and the incidence of stroke among family planning acceptors.Conclusion:Combined oral contraceptives affect venous thromboembolism and stroke in family planning acceptors.