India has a large population of Persons with Disability (PWD) who are in need of education, employment and Rehabilitation services. NSSO Survey indicates, India is having 18.49 millions PWD forming about 1.8% of the total population. The prevalence of locomotor disability is highest among all types of disabilities followed by hearing disability and blindness. Prevalence and incidences of disability has been changing, over the years, with the causes of disability. Over the years, the concept of Rehabilitation has undergone a sea change in its approach. Today, the care and management of PWD does not mean only educating and training the PWD but also empowering PWD to be integrated with normal mainstream in their own community. The introduction of stem cell in cases of spinal cord injury has given a new ray of hope. Similarly with CAD-CAM technology a better quality of Prosthesis/Orthosis is now possible in shortest time which is a new revolution in fabrication, fitting and trial of aids/appliances. This book is also useful to students of Physiotherapy, Occupational therapy, Prosthetic and Orthotics who wish to keep abreast and update in common locomotor diseases/ disabilities and also interested in their comprehensive rehabilitation.